To test the effectiveness of his new version of amphotericin B, Wasan sent samples to a laboratory at another university, where it was used to treat mice infected with visceral leishmaniasis.
"And the results were just remarkable," he says. "We found greater than 99 percent reduction in the parasitic load in less than five days, and remarkably, in 60 percent of the animals, we completely eradicated the infection."
After the positive animal-test results, Wasan is now seeking funding to begin human trials.
The new formulation for amphotericin B may be useful against other conditions, too. The drug is also used to treat fungal infections in people with compromised immune systems, such as HIV patients and organ transplant recipients.
"The impetus originally to do the work was actually in the fungal infections," Wasan says. "Physicians wanted a cheaper, more accessible form of amphotericin B than the injectable. So the oral formulation was going to help in those situations as well. So, yeah, there actually are multiple uses for this formulation."
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2013-11-27
2013-11-27
2013-11-27
2013-11-27
2013-11-27
2013-11-27