Heart Failure Drug Not as Effective on US Patients
Study finds beta blockers work much better elsewhere
August 22, 2011
Beta blockers, used for patients experiencing heart failure, vary in effectiveness in different geographic regions, according to a new study.
Before new drugs are approved for use, they go through a multi-step approval procedure. In recent years, the process has become more globalized, but a new study suggests that the results of clinical trials in one country or region may not be relevant for patients in another.
For many new drugs, the biggest market may be in Europe and North America, but when the testing moves out of the lab and into human subjects, increasingly the venues include low- and middle-income countries.
As a researcher and cardiologist, Dr. Christopher M. O'Connor, of the Duke University Medical Center in North Carolina, has seen studies of new-drug effectiveness that seemed to have different results in different countries. So he combined the results from several studies investigating the effectiveness of drugs called beta blockers for patients with heart failure.
The studies enrolled patients in both the United States and other countries. Overall, O'Connor says, beta blockers reduced the risk of death by about 32 to 35 percent.
"But what we found is that, in the United States, it was only an eight percent reduction; in the rest of the world it was a 36 percent reduction," he says.
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