Diet May Explain Infection Deaths in Obese Patients
Study suggests new way to fight sepsis infection
21 October 2010
Sepsis is much more likely to kill obese patients and a high-fat, high-calorie diet might be the reason why, over-stimulating the body's immune response to the sepsis infection.
Sepsis is a severe infection that can often be fatal, particularly in obese patients. Now, a new study suggests why obese patients are at greater risk and suggests a possible new approach to treatment.
Sepsis is seven times more likely to kill patients who are obese, and one possible reason is that the typical Western diet over-stimulates the body's immune response to the sepsis infection.
To test the theory, Louisiana State University professor Chantal Rivera fed a Western style diet to laboratory mice.
"It was high in saturated fat, high in cholesterol, high in sugar," she said in a telephone interview. "And then [we] exposed them to a model of sepsis and tried to figure out why the inflammatory response in these septic mice that had been fed long-term with this high-fat, high-calorie diet, whether or not the inflammation would be worse — and it was — and then we tried to go after what would make the inflammatory response worse."
In her study, Rivera found a clue in a particular protein that flourished in the mice that got the Western diet.
"And what we found is that, you get this increase in proteins on the cell surface called receptors, and in particular the receptor called toll-like receptor four was enhanced, compared to mice that were fed a normal rodent chow."
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