While it's well known that HIV is transmitted sexually, how the virus crosses genital mucus membranes to reach its targets in the immune system is less well understood.
虽然我们都知道性行为是艾滋病病毒传播的主要方式之一,但是我们却对HIV是如何穿过生殖器粘膜,最终抵达免疫系统中的靶细胞知之甚少。
Previous research has looked at biochemical measurements or morphology at various points during HIV transmission to investigate this process, but in a study published in the journal Cell Reports, researchers in France constructed an in vitro model of urethral mucosa in order to view it from start to finish.
在先前的研究中,科学家主要从生化指标或形态学的角度去研究HIV传播的过程,但在发表在《细胞报告》期刊的一项研究中,来自法国的研究人员构建了体外尿道粘膜模型,来观察整个传播过程。
"We had this global idea of how HIV infects this tissue, but following something live is completely different. The precise sequence of events can be defined, and we were very surprised by them," says senior researcher Morgane Bomsel, a molecular biologist at the Institut Cochin.
资深研究员、柯尚研究所的分子生物学家摩根·邦塞尔表示:“我们对关于HIV如何感染这种组织已经形成了一种全局观点,但是通过实时可视化观察对此进行追踪是一种完全不同的方法。HIV传播事件的精确发生顺序就能够被确定,我们对此感到非常吃惊。”
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