Long QT is primarily an inherited disorder, but Keating said that some individuals may develop a drug-inducible form of the syndrome while they are on certain medications. Many drugs are known to induce long QT, including erythromycin, antihistamines, and some anti-arrhythmic medications.
The reason these drugs can have a potentially lethal impact on some people and not others is unknown. “We believe that drug-inducible long QT may result from subtle mutations in cardiac ion channels,” Keating said. Up to six percent of people in the United States may have these more subtle mutations, he said.
- Genes discovered for sudden death syndrome, a silent killer of young adults, hhmi.org, May 1, 1995.
3. TRUMP: “You understand the expression ‘prime the pump’? … I came up with it a couple of days ago and I thought it was good. It’s what you have to do. We have to prime the pump.”
The Facts: He didn’t coin that phrase. It’s a well-used metaphor for generating faster growth, first made popular as an economic analogy more than 80 years ago during the Great Depression.
The Merriam-Webster dictionary quickly tweeted that the phrase “priming the pump” has been around since the early 1800s. Literally, it’s about pouring water into a pump to allow it to create suction. The phrase was commonly used by mining publications during the 1920s, but it took on new significance after the economy crashed during the Depression.
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