21. Which of the following best states one of the main conclusions of the passage?

　　 Although the techniques for pancreas transplants appear to be theoretically correct, there are problems that must be solved before the operation can be used as a treatment for diabetes.

　　 Although the techniques for pancreas transplants are still being developed, the experimental results show that the operation will be a successful treatment for diabetes in the near future.

　　 Although pancreas transplants are reliable, many diabetics are reluctant to undergo the operation because of the side effects of immunosuppressive drugs.

　　 Although pancreas transplants alone are not generally successful, the operation can be used in conjunction with other procedures to treat diabetes.

　　 Although pancreas transplants have not been successful in treating diabetes, research indicates that other procedures may soon be developed.

　　22. According to the passage, widely spaced doses of insulin can cause.

　　 reversal of normal kidney function

　　 delay in the onset of diabetes

　　 radical changes in the concentration of blood glucose

　　 restoration of normoglycemia

　　 marked variations in the islets of Langerhans

　　23. According to the passage, a periodic high concentration of blood glucose in diabetics is a possible cause of

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