The team have started looking, but could find no clear pattern except that one form ofnicotine-induced acetylation, that of H3 histones, could be blocked by a molecule calledRGZ.
研究团队已经开始研究这一问题,但目前只研究出一种明确的模式:尼古丁会引起H3组蛋白的乙酰化,
This molecule is also known to protect lungs against the asthma-causing effects ofnicotine.
进而导致一种叫做RGZ的分子受到抑制,而目前已知RGZ分子可以保护肺脏,使其免受由尼古丁引起的哮喘。
That suggests it is the acetylation of H3 histones rather than the methylation of DNA itselfthat is creating the effect.
这表明由尼古丁引起的哮喘是源于H3组蛋白的乙酰化,而非DNA自身的甲基化作用。
Which crucial genes these histones surround remains obscure.
研究团队目前没有研究出这些受影响的组蛋白包含着哪些关键基因,
Nor have the team yet found out whether the epigenetic effect they have discovered reachesfurther than grand-offspring.
也没有发现表观遗传的影响是否会延续至第三代以下的后代。
If it does, though, it suggests that epigenetics really might act like the biblical curse:
然而,如果有研究表明后生效应会世代相传的话,这就表明表观遗传现象真真是有如圣经上的诅咒:
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