Ipilimumab s success has spurred the development of further antibodies that work in similarways.
易普利姆玛的成功激励研究人员深入研究有着类似工作机制的抗体。
Nivolumab and lambrolizumab gum up another surface protein, PD-1; and a fourth, so newthat it still goes by its laboratory identifier of MPDL3280A, binds to PD-L1, a protein thatwould otherwise help PD-1 to do its job.
Nivolumab和lambrolizumab扰乱另一种表面蛋白PD-1。第四种蛋白最近才发现,还使用着实验室标识符MPDL3280A,它可以绑定到PD-L1上,而PD-L1会反过来协助PD-1蛋白完成任务。
Though they have slightly different modi operandi, all four antibodies work by shutting downbiochemical checkpoints that limit the proliferation of lymphocytes.
尽管方式稍微不同,四种抗体采取关闭生物检查站,解除淋巴细胞扩散限制的方法,
Hence the name checkpoint inhibitors.
因此得名检查抑制剂
In the original trials of ipilimumab, 11% of patients responded.
易普利姆玛在最初进行试验时,有11%的病人对药物产生反应。
That might not sound many, but those who did respond often did so stronglysurviving insome cases for years with no evidence of disease.
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