多米提奇博士在诺华制药公司工作,文特尔博士是位于圣地亚哥J克雷格文特尔的同名创始人。本周《科学转化医学》杂志刊载了二人创纪录的研发结果。
It began with the transmission to them from America s Biomedical Advanced Research andDevelopment Authority of the sequence data for the haemagglutinin and neuraminidasegenes of a unknown flu virus.
一开始,他们得到美国生物医学高级研究所和发展管理局的序列数据,关于不知名的流感病毒的血凝素和神经氨酸酶基因的数据。
The team took this information and used it to make DNA that contained both the genesequences themselves and the genetic apparatus needed to let a cell read thosesequences and produce proteins from them.
小组利用数据制作包含两种成分的DNA,分别是基因本身序列和需要细胞识别这些序列并且从中产生蛋白质的基因组织。
They then put these pieces of synthetic DNAwhich were, in effect, tiny chromosomesintocell cultures derived from dog kidneys, which have been found particularly effective for thiskind of work.
之后,研究人员将合成的DNA碎片植入从犬类肾脏中提取的细胞培养物中。经研究发现,犬类肾脏的细胞培养物质非常适合此类实验。
The dog-kidney cells duly churned out viruses, suitable for seeding the process of vaccinemanufacture, that contained the proteins in question.
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