简达博士注意到过去对于甲基苯丙胺疫苗的试验总是围绕着蛋白质载体或者辅助剂在进行,
rather than tinkering with the haptens.
而忽略了半抗原。
He thought he might be able to change that, on the basis of work he had carried outpreviously, trying to design a vaccine against nicotine.
他认为基于之前为设计一种尼古丁疫苗而开展的研究,他将改变这一状况。
In particular, nicotine is a highly flexible molecule.
特别是尼古丁的分子存在很高的变化性。
That makes it hard for the immune system to recognise.
这使得免疫系统难以识别他们。
To overcome this, his team on the nicotine project had to work out how to fix their haptensto the carrier protein in a way that rendered them less capable of twisting and turning, andthus made them easier for the immune system to identify.
为了克服这一问题,其尼古丁疫苗项目团队必须找到如何将半抗原固定在蛋白质载体上的方法,使得这些分子不那么容易扭曲转动,从而更容易被免疫系统识别。
In the new study, Dr Janda and his colleagues report that they have performed a similar trickwith methamphetamine haptens.
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