Just as it moves rapidly from the lungs into the bloodstream, nicotine also easily diffuses through capillary walls. It then migrates to the spaces surrounding neurones ganglion cells that transmit nerve impulses throughout the nervous system. These impulses are the basis for our thoughts, feelings, and moods. To transmit nerve impulses to its neighbour, a neurone releases chemical messengers known as neurotransmitters. Like nicotine molecules, the neurotransmitters drift into the so-called synaptic space between neurones, ready to latch onto the receiving neurone and thus deliver a chemical message that triggers an electrical impulse.
The neurotransmitters bind onto receptors on the surface of the recipient neurone. This opens channels in the cell surface through which enter ions, or charged atoms, of sodium. This generates a current across the membrane of the receiving cell, which completes delivery of the message. An accomplished mimic, nicotine competes with the neurotransmitters to bind to the receptors. It wins and, like the vanquished chemical, opens ion channels that let sodium ions into the cell. But theres a lot more nicotine around than the original transmitter, so a much larger current spreads across the membrane. This bigger current causes increased electrical impulses to travel along certain neurones. With repeated smoking, the neurones adapt to this increased electrical activity, and the smoker becomes dependent on the nicotine.
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