The 25-year-old Du, who set a new Paralympic record in the morning's heat at 1 minute and 42.95 seconds, took the winning time further down to 1:35.21 in the finals, shaving 5.87 seconds of the former world mark.
"I only won a silver last time, missing the gold, which I had wanted badly for three years. This time I competed on the home ground and it made me feel more excited and special," said the winner.
Du's harvest was also the hosts' only gold medal on the first day of swimming contest. China took the second place on the gold medal tally with one gold, four silvers and five bronzes.
Australia finished the third place with two silvers less than China but their ace swimmer Peter Leek beat the host's favorite Wang Xiaofu in men's 100m butterfly S8.
The in-form Aussie not only won the gold, also refreshed the world record twice of the day.
"I knew I could break the record again. It was great, I was feeling fairly nervous before the race.
"I have been waiting for this moment and it has finally come. It has been very hard. It has been 18 years of hard work, but when you win that Gold medal it feels like it all pays off." said the beaming winner with tears swelling in the eyes after the clash.
The other eight new world records were created by Patricia Valle of Mexico, Tamas Sors of Hungary (twice), Dmitry Kokarev of Russia, Dzmitry Salei of Belarus, Daniel Dias of Britain, Teresa Maria Perales of Spain, and Du Toit Natalie of South Africa.
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