Robbie Keane drew a blank on his return to White Hart Lane despite a busy debut, flashing a header just over and shooting narrowly wide in the second half.
In the opposite lineup, Emmanuel Adebayor had to limp off after a hamstring injury and Russia star Andrey Arshavin was left an unused substitute on his first day in Gunners' uniform.
One goal was enough for United to accumulate the advantages for a hopeful hat-trick of league titles although West Ham matched the title favourites for long periods.
England new boy Carlton Cole had the hosts' best chance in the first half as his attempted chip was plucked out of the air by Vander Sar after he had been sent clear.
United, not at their best, were struggling to create chances until a moment of magic from skipper Giggs secured the victory built on solid defence.
Paul Scholes swept a fine ball out to the left flank and Giggs cut inside before curling a right-footed shot beyond keeper Robert Green.
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2020-09-15
2020-09-15
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2020-09-15