"It's fun to be the marked guy and everybody is gunning for you," said Fish, who reached the final in San Jose, California, this month.

Spadea, who reached at least the quarters here every year since 2004, has been fighting a virus and fever since his first-round match.

"I think there are some factors, and those factors being that he's improved, he's playing well and I was under-conditioned," Spadea said. "I just didn't have a lot of energy out there and my whole game thrives on energy, and grinding, and getting an extra ball back, and winning ugly, really."

Fish will next meet sixth-seeded Florent Serra of France, who overcame Mischa Zverev of Germany for the first time, 6-3, 4-6, 6-4.

Seventh-seeded Jeremy Chardy of France reached his third quarterfinal of the year with a 7-6 (4), 7-5 win over Andrey Golubev of Kazakhstan.

Chardy, who reached his first career final in Johannesburg this month, will face Marcos Baghdatis in the quarterfinals. The Cypriot outlasted Dudi Sela of Israel, 7-6 (7), 6-3.

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