David Villa, whose career began at Sporting, scored his 22nd goal of the season with a penalty in the 56th, but Mate Billic took advantage of slack defending in the 71st to head home before Mata's ninth strike of the season condemned Sporting to its league-high 19th defeat.
Valencia has 49 points, Villarreal 48 and Atletico Madrid joined Malaga at 46 after Sergio Aguero and Simao Sabrosa netted in a 2-1 victory at Deportivo La Coruna.
Jaime Gavilan's 82nd-minute score allowed Getafe to snap a five-game losing streak and pick up a 1-0 victory at Sevilla.
Sevilla stayed third with 57 points.
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