The first seeded player to lose was No. 17 James Blake, who was beaten by Andreas Seppi of Italy 5-7, 4-6, 6-7 (5). Blake failed to convert a set point in the third set and squandered a 5-0 lead in the tiebreaker.
Blake also lost in the first round at the French Open last month.
Another American, No. 28-seeded Mardy Fish, never lost serve and led 6-3, 6-2, 4-1 when Argentina's Sergio Roitman retired with a right shoulder injury.
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