Buoyed by that news Barcelona started strongly forcing three corners in the first 10 minutes. From the third of those Pique opened the scoring: Xabi Hernandez crossed, Thierry Henry got a touch and Pique finished at the far post.
Inter remained true to its defensive style of play and the game ran the risk of getting out of control as the Italians committed a series of fouls in the middle of the park.
Pedro Rodriguez doubled Barcelona's lead after 25 minutes, volleying home a cross from right back Dani Alves.
If Inter had any hopes of getting back into the match in the second half, they were soon to disappear. Although Jose Mourinho's side tried to pressure further up field, Barca remained in control.
With Xabi and Iniesta back to their best, Barcelona was able to move the ball around to the frustration of the Italians.
The fact that Inter only managed three shots in all of the game says everything about Barcelona's control and that will give Guardiola's men the perfect morale boost for the visit of Real Madrid next Sunday.
Elsewhere Dragutinovich's own goal at the end of the first half saw Sevilla slip to its first European defeat of the campaign away to Rumanian side Urinrea Urziceni.
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