Higgins had chance to make amends in the 16th frame, but he missed a crucial red to a top-corner pocket when leading 49-0. Ding was able to come back and win the frame, leaving the score 9-7 in his favour.
Higgins took another frame with a 115 break, but Ding's 75 break in the final frame was enough to take him to 10-8 and victory.
Ding told the Guardian newspaper: "It's been a crazy week. I've beaten four of the five top players. It's brilliant.
"I concentrate more. Sometimes I don't play the best shot but I keep my mind clear and tell myself not to get angry."
Ding had previously won the UK Championship, in 2005 when he beat snooker legend Steve Davis 10-6 at the Barbican Centre in York, in the north of England.
This victory at the Telford International Centre, in the English Midlands, is his fourth ranking title victory, joining the previous UK Championship win, the Northern Ireland Trophy in 2006 and his first ranking win the China Open in Shanghai in 2005.
The win is a welcome return to form for a young player who many have tipped to be world champion one day.
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