Marcos Senna gave Villarreal a lifeline after 30 minutes, hitting home another spectacular free kick after Kaka had pushed Matilla.
Higuain reopened a two goal lead for the home side after 54 minutes following good work from Ronaldo only for Nilmar to again bring Villarreal back into things following a neat exchange of passes with Robert Pires.
That was the end of Villarreal's challenge and Higuain scored his second with 20 minutes left following a Marcelo cross.
Kaka added his second of the night with 10 minutes left and Alonso scored Madrid's second penalty of the game with three minutes left after Pires was adjudged to have brought down Ronaldo.
Real Madrid's Cristiano Ronaldo (2nd, R) from Portugal celebrates after scoring against Villarreal during a Spanish La Liga soccer match at the Santiago Bernabeu stadium in Madrid, Sunday, Feb. 21, 2010.
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