Wolfsburg midfielder Zvjesdan Misimovic opened the scoring 21 minutes into the match; defender Sascha Riether and striker Edin Dzeko extended the lead.
Dzeko marked his 22nd goal this season and is the Bundesliga top scorer of the season 2009/10.
Minutes before final whistle Frankfurt striker Halil Altintop scored the consolation goal.
Bochum slipped into second division after they lost at relegation battle 3-0 to Hannover.
Hannover midfielder Arnold Jan Bruggink smoothed the way for the victory at the relegation battle with his early opener.
Striker Mike Hanke and midfielder Sergio Pinto sealed a 3-0 victory for Hannover. Hannover ends the campaign on 15th position.
Nuremberg defeats Cologne thanks to a brilliant dead ball goal by midfielder Andreas Ottl two minutes before the final whistle.
Nuremberg will have to participate at a relegation match against second division team Augsburg to remain in first division.
Bayern Munich's Mark van Bommel, coach Louis van Gaal and Bayern Munich's Arjen Robben (L-R) hold the German soccer championship trophy after their first division Bundesliga soccer match against Hertha Berlin in Berlin May 8, 2010.
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