The big hitter gave Nadal his first defeat at Roland Garros in the fourth round last year, but lost the final to Swiss Roger Federer, whom then grabbed his first clay court Grand Slam title so as to complete his career Grand Slam sweep.
In this year's quarterfinals, Soderling fought back from one set down to see off the top seed Federer in four sets.
Serena Williams and Venus Williams from the United States took victory in the women's doubles final as the top seeds defeated Kveta Peschke from Czech and Katarina Srebotnik of Slovenia 6-2, 6- 3 after 73 minutes.
But Serena Williams has no chance to play the singles final as the top seed was beaten by Australian Samathan Stosur 2-6, 7-6 (2) and 6-8 in the quarterfinals.
Venus Williams, seeded second in the singles, suffered earlier exit while she was beaten by Russian Nadia Petrova 6-4, 6-3 in the last 16.
The seventh seed Stosur is going to lock horns with Italian Francesca Schiavone on Saturday.
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