Top seed Rafael Nadal advanced to the fourth round of the U.S. Open, while Venus Williams and Kim Clijsters moved into the quarterfinals in the women's singles on Sunday.

Fourth seeded Andy Murray suffered the biggest upset of US Open so far as the British number one was edged out of the US Open by Swiss Stanislas Wawrinka in an epic four-set clash, scoring 7-6 (7-3), 6-7 (4-7), 3-6, 3-6.

Nadal moved one step closer to winning the only Grand Slam tennis title that has eluded him with a 6-4, 6-4, 6-2 win over Gilles Simon of France.

Nadal, who has won all 46 of his service games so far, next will face 23rd-seeded Feliciano Lopez. They are among five seeded Spaniards in the fourth round.

Number 8 Fernando Verdasco and number 10 David Ferrer also won on Sunday. Also advanced into next round was Sam Querrey, a 20th-seeded American who won 6-3, 6-4, 6-4 against 14th-seeded Spaniard Nicolas Almagro.

Two-time U.S. Open winner Williams and defending champion Clijsters reached the last eight in very different fashions.

Williams needed one hour, 54 minutes to overcome her own serving problems and Israel's Shahar Peer 7-6 (7-3), 6-3. The American missed 52 percent of her first serves, struggling with the ball toss in the swirling wind.

Third-seeded Williams lost her serve twice in the first set against the 16th-seeded Peer and wasted six set points. She also had her serve broken once in the second set by Peer.

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