Wawrinka, 25th-seeded, will challenge Mikhail Youzhny as the 12th-seeded Russian beat Spain's Tommy Robredo 7-6, 6-2, 4-6, 6-4.
Wawrinka joins five-time U.S. Open champion Roger Federer in the last eight, making it the first time two Swiss men have reached this stage of the same Grand Slam since tennis turned professional in 1968.
Stanislas Wawrinka (L) of Switzerland shakes hands with Sam Querrey of the U.S. after winning their match during the US Open tennis tournament in New York, September 7, 2010
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