Alex Ferguson got a thunderous reception from United fans still digesting Rooney's decision to leave the club ahead of their Group C clash with Bursaspor, which was decided by a superb Nani strike after just seven minutes.
The win sees United lead Group C on seven points from three games while Glasgow Rangers sit second in Group C on five points after playing out a 1-1 draw with Valencia.
In Group B, Schalke put their Bundesliga woes behind them - where they are rooted in the relegation zone - as two goals from Raul and a third from Jose Manuel Jurado helped Felix Magath's side to a 3-1 win at home to Hapoel Tel-Aviv.
Schalke are now second in the group on six points, three behind leaders Lyon, who enjoyed a 2-0 win at home to Benfica.
Jimmy Briand put the French side in front on 20 minutes just seconds after Michel Bastos hit the woodwork with a shot from the edge of the area.
Benfica's hopes of staging a comeback all but ended two minutes before the break when Nicolas Gaitan was sent off for a second bookable offence and, in a similar sequence to Lyon's opener, Lisandro Lopez secured the win after a Briand effort came back off a post.
Barcelona top Group D on seven points thanks to a 2-0 win against Copenhagen, who remain in second spot, one point adrift.
Messi opened the scoring on 19 minutes with a well placed shot but the Spanish champions had to wait until the last minute to be sure of all three points when the Argentine added his second of the game.
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