But four minutes later, striker Jermain Defoe was shown a red card after he caught Villa defender James Collins with his elbow as they challenged for a high ball.
Spurs were unaffected by their numerical disadvantage and Van der Vaart scored again in the 67th minute before being replaced by Peter Crouch.
Marc Albrighton pulled one back in the closing stages but the late goal couldn't save them from a loss.
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