Lecce grabbed the win through Carlos Grossmuller in the 74th.
Similarly, fourth-placed Roma could not close the gap on Milan when they went down 2-1 to Sampdoria at the Stadio Luigi Ferraris.
The visitors, who took the lead in the first period thanks to a powerful run and shot from Mirko Vucinic, looked comfortable until substitute Juan underhit a backpass and compatriot Julio Sergio could only bring down Angelo Palombo.
The goalkeeper was dismissed without protest and Nicola Pozzi blasted in the resulting penalty before Juan failed to clear a ball in the box and former Roma winger Stefano Guberti nipped in to score an 84th-minute winner
Inter Milan's renaissance under new coach Leonardo continued when they scored a 2-1 win over Catania away from home.
Alejandro Gomez gave Catania the lead after 71 minutes, but a brace from midfielder Esteban Cambiasso helped secure all three points for the champions and made it two wins from two for their new boss.
Bologna climbed to 10th spot in the table with a 2-0 win over Bari, while Fiorentina enjoyed a 3-2 win over Brescia.
Brescia led 2-0 at half-time thanks to goals from Alessandro Diamanti and Nicolas Cordova, but Fiorentina hit back in the final 18 minutes of play with goals to Alberto Gilardino, Mario Santana and Adem Ljajic sealing a valuable three points.
Cagliari claimed a 2-1 away win over Parma, while Genoa's trip to Cesena and Palermo's visit to Chievo Verona both resulted in goalless draws. Enditem
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