"Thank you, NPR's legal affairs correspondent, Nina Totenberg."
Scientists at the National Cancer Institute said they have found a new method for treating cancers of the lung, liver and colon in test animals. The scientists report the method cured cancer of the liver and colon in mice. NPR's Lori Garrett has details.
Doctor Steven Rosenberg has done it again. Last year, Rosenberg stunned the medical community with word he had successfully treated some human cancer patients with a revolutionary type of therapy. But some of the patients suffered serious side effects from the treatment. One died as a result. So Rosenberg has been busy working on improvements. Today, in Science magazine, Rosenberg reports studies in mice show he may have found the right treatment.
Rosenberg is working on ways to trick the body's immune system into successfully attacking tumor cells. The immune system is complicated. Any successful attack on cancer cells involves a vast army of special immune chemicals and cells. A key chemical is Interleukin-2. It stimulates cells of the immune system to do their jobs and kill enemy targets such as cancer cells. Interleukin-2 is now readily available, cheaply manufactured because it can be made through genetic engineering techniques.
Rosenberg and his colleagues initially tried to grow human white blood cells in the laboratory in dishes full of Interleukin-2. The idea was to stimulate those white blood cells, make them good fighters, and then inject them back into the cancer patients where they would tackle the enemy tumor cells. It worked, but the doses of Interleukin-2 that were required were toxic, even deadly.
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