The medication is on track to become just the third oral drug available to M.S. patients, and potentially the safest and most effective, experts said. The second oral drug, called Aubagio, was approved just last week.
The new trials, published online in The New England Journal of Medicine, found that the drug BG-12, developed by Biogen Idec, reduced relapsing M.S rates(旧病复发率)in patients by about 50 percent. The drug also obviously reduced the frequency of new brain damage , and slowed the progression of disease compared with a placebo(安慰剂).
In the two clinical trials, called Define and Confirm, patients were divided into two groups at random, taking 240 milligrams of BG-12 either twice or three times a day. Patients in a third group took a placebo. The combined results showed that the drug reduced the relapse rate by about 50 percent.
Taking BG-12 twice a day reduced the number of newly enlarging brain damages by 71 percent to 99 percent. The Define trial found a statistically significant 38 percent reduction in the progression to disability. The most frequent side effects were a temporary flushing(脸红)and warm feeling and other symptoms including nausea, diarrhea, cramping and vomiting. Though both types of side effects were common, they tended to reduce after the first few weeks of use and were tolerated by most patients.
However, Interferons, the drugs most commonly used in relapsing M.S., reduce relapses by about 30 percent, and have not been shown to slow the progression of the disease and disability. The newly approved Aubagio also reduces relapses by about 30 percent, and it has the advantage of being an oral drug.
【2017届四川省剑阁县高考英语一轮复习阅读理解训练:6(含解析)】相关文章:
★ 2014高考英语(新人教版)一轮基础训练(11)A、B卷(附答案或解析)
最新
2017-04-24
2017-04-24
2017-04-24
2017-04-24
2017-04-21
2017-04-21