Raul Cano, who has pioneered the research at the California
Polytechnic
State
University, said the ancient antibiotics had been successful in fighting drugresistant strains of staphylococcus (葡萄球菌),a “superbug” that had threatened the health of patients in hospitals across the globe. He now intends to establish whether the antibiotics might have side effects.
“The problem is how toxic they are to other cells and how easy they are to purify”, said Cano.
Cano's findings have been acknowledged as a breakthrough. A biotechnology company, Ambergene, has been set up to develop the antibiotics into drugs. If any ancient microbes are revived (复活)
that resemble presentday disease, they will be destroyed in case they escape and cause new epidemics. Drug companies will be anxious to study the chemical structures of the prehistoric antibiotics to see how they differ from modern drugs. They hope that one ancient molecule could be used as a basis to produce a range of drugs.
However, even the use of ancient antibiotics may not stop the rise of drugresistant bacteria. Stuart Levy warned that the bacteria would eventually evolve to fight back against the new drugs. “There might also be an enzyme already out there that can degrade it. So the only way to keep the life of that antibiotic going is to use it sensibly and not excessively,” he said.
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