Taking a low dose (剂量) of aspirin every day can prevent and possibly even treat cancer, fresh evidence suggests. Prof. Peter Rothwell, from Oxford University, and his colleagues, who carried out the latest work, had already linked aspirin with a lower risk of certain cancers, particularly bowel(肠) cancer. But their previous work suggested people needed to take the drug for about 10 years to get any protection. Now the protective effect occurs much sooner—within three to five years—based on a new analysis of data from 51 trials involving more than 77,000 patients. And aspirin appears not only to reduce the risk of developing many different cancers in the first place, but may also stop cancers spreading around the body.
Taking a low (75 — 300mg) daily dose of aspirin appeared to cut the total number of cancer cases by 25 % after only three years—there were nine cancer cases per 1,000 each year in the aspirin-taking group, compared with 12 per 1,000 for those taking dummy pills. It also reduced the risk of a cancer death by 15% within five years (and sooner if the dose was higher than 300mg). And if patients stayed on aspirin for longer, their cancer death risk went down even further—by 37% after five years.
Low-dose aspirin also appeared to reduce the probability that cancers, particularly bowel, would spread to other parts of the body, and by as much as half in some instances. However, Prof. Rothwell says for most fit and healthy people, the most important things they can do to reduce their lifetime cancer risk is to give up smoking, take exercise and- have a healthy diet.
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