The blast comes a day after 13 people were killed in a bomb attack by separatists in Balochistan province. The long-running insurgency(叛乱,暴动) in Balochistan is separate to the Taliban campaign which has raged inside Pakistan since 2008.
Except for an attack on a courthouse last month, the Pakistani capital has been relatively peaceful in recent times, says the BBC's Mike Wooldridge in Islamabad.
Eleven people were killed in the assault on the judicial complex, for which a splinter group of the Pakistani Taliban admitted responsibility.
The casualty toll in the latest attack would make it the deadliest in the capital since the bombing of the Marriott Hotel in 2008, our correspondent adds.
There is currently a truce between the Pakistani Taliban and the government as talks are under way to find an end to the insurgency.
The peace talks were a key campaign pledge for Mr Sharif before he was elected to office for a third time last year.
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