The Chilean interior ministry told the BBC that one of the main roads outside Iquique was cut off because of hillside debris.
The ministry says that partial landslides have also taken place between the towns of Putre and General Lagos.
The interior minister also told Chilean TV that some 300 women inmates had escaped from a prison in Iquique. The authorities are reported to have deployed a planeload of special forces to guard against looting.
Chilean Interior Minister Rodrigo Penailillo said President Michelle Bachelet was being kept informed. She is to travel to the affected area.
"We have taken action to ensure public order in the case of Iquique, where we've had a massive escape of more than 300 female prisoners, so that the armed forces and police can coordinate and provide security to the residents," he said.
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