Further damage may not be known until dawn.
The quake shook modern buildings in Peru and in Bolivia's high altitude capital of La Paz - more than 470km from Iquique.
At least eight strong aftershocks followed in the few hours after the quake, including a 6.2 tremor.
The Chilean interior ministry told the BBC that one of the main roads outside Iquique was cut off because of hillside debris.
Partial landslides have also taken place between the towns of Putre and General Lagos.
The interior minister also told Chilean TV that some 300 women inmates had escaped from a prison in Iquique.
[.Com]
Officials later said that 26 of them had been recaptured.
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