None of the patients had signs of rabies infection, even though 18 months had passed since their transplants. Before these cases, researchers thought that rabies transmission after transplantation would be rapid, occurring within six weeks. People who receive transplants typically take drugs to suppress (抑制) their immune systems,
making infections even more likely.
The three patients received rabies treatment, and still show no signs of illness. It's possible that the type of rabies virus that infected these patients takes a longer time to make people sick,
the researchers said.
Patients may also have been exposed to a low dose of the virus. The report raises questions about how rabies viruses spread after transplantation,and where they live in the body when the infection is not active,
said the
researchers from the
Centers
for Disease Control and Prevention.
Because rabies infections are so rare, screening all organ donors for rabies infections is not practical, the researchers said. However, doctors should develop
a plan to help them recognize infectious encephalitis — a brain infection that can be caused by rabies — in donors. Organs from donors with infectious encephalitis should only be used in extreme circumstances, the researchers said.
The donor in this case frequently engaged in hunting and animal trapping, and had got many bites from a raccoon(浣熊) before his death.
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