Djokovic could meet David Ferrer, Roberto Bautista Agut, fourth-seeded Grigor Dimitrov and the eighth seed David Goffin en route to the semifinals.

Thiem snapped Nadal's 50-set winning streak in the quarter-finals in Madrid, before losing the final to Zverev. That was also Nadal's sole loss in clay season this year.

Thiem could set up a revenge clash against Zverev in the quarter-finals, given that the German already overcame last year's runner-up Stan Wawrinka on the way.

After being rejected for a seeding position, three-time winner Serena Williams, ranked 453rd, will play her her first Grand Slam match against Czech Kristyna Pliskova in more than one year.

Williams was already pregnant when she won the 2017 Australian Open title, before giving birth to a daughter last September.

She is poised to meet her long-time rival Maria Sharapova, who also made a return to Roland Garros after two years, in the fourth round.

Sharapova missed the 2016 tournament due to drug suspension, and failed to receive a wild card from organizers last year.

Prior to the highly-anticipated clash with Williams, Sharapova faced uphill challenge against another Pliskova from the Czech Republic, the sixth-seeded Karolina Karolina in the third round.

William's elder sister Venus may face two Chinese players in a row. Wang Qiang will be her first round opponent for the second straight year, with Wang Yafan waiting for her in the second round.

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