Lee is credited with bringing a sense of humanity and self-doubt into previously perfect superheroes, and for tackling tough social issues, like racism and prejudice.

"He would talk about prejudice, racism," said Robert Scott, owner the San Diego-based comic book store, Comickaze. "I mean the X-Men, here was a group of people who were only trying to do good things and only trying to help and they were constantly ostracized by being mutants."

"That was the revolution that Stan Lee did," says David Goyer to the press, screenwriter of Marvel's "Blade." "He was the first one to create, with Spider-Man, superheroes who doubted themselves, who were tormented, who were unhappy."

"The person viewing the cartoon or reading the book should have something to think about, not just look at mindless pages of running around," Lee said.

"What Stan did in the 1960s was really to go out there and evangelize, to be a P.T. Barnum or a Sol Hurok, a promoter of the fact that comics weren't just a children's medium and certainly not just a stupid children's medium," said comic book writer and executive, Paul Levitz.

A savvy businessman, Lee spearheaded Marvel from a tiny geek shop to the top of the Hollywood food chain. His characters are now responsible for the biggest box office smashes, revenues of billions worldwide, and employment for tens of thousands of around the globe.

Praise and accolades from his Hollywood peers and colleagues was unstinting.

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