In the women's race, Rono will need to help Kenya wrest the title from the grip of several Ethiopian runners, including Mulu Seboka, with whom Rono battled last year.
With a 2:21:39 personal best set five years ago, 2017 Hamburg Marathon winner Rono is the fastest woman on the Guangzhou entry list.
She won the Doha Marathon in January last year and clocked a season's best of 2:28:52 to finish third in Dongying in May 2017.
"There are younger runners coming through making it harder by the day," said Rono. "But I always focus on my training and my own strength in entering these international competitions. I believe I still have something to offer and that is winning."
Rono's compatriot Anne Cheptanui Bererwe is also among the favorites in Guangzhou. The 35-year-old improved her best time by more than one minute to finish second in Chongqing in March in 2:27:18.
This will be the second edition of the Guangzhou Marathon after it was updated to an IAAF Silver Label race.
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