Liverpool had to dig deep against Newcastle and it wasn't until the 86th minute that Divock Origi gave them three vital points, but those efforts could take their toll on Tuesday.
Liverpool boss Jurgen Klopp confirmed after the game that Roberto Firmino will miss Tuesday's game and the rest of the season with a groin injury, while Mohamed Salah is a major doubt after being stretchered off with a head injury following a collision with Newcastle goalkeeper, Martin Dubravka.
Naby Keita is also out for Liverpool with the groin injury he suffered in the Camp Nou, while Barca lost Ousmane Dembele to a hamstring injury on Saturday.
Liverpool will hope for an early goal to put the pressure on Barcelona, but everyone knows a goal for Barca will leave them needing to score five.
Barcelona won't have forgotten how last season they saw a 4-1 first leg advantage overturned by Roma, but a year ago they didn't have the luxury of giving Messi a week's rest between matches.
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