A win for Sevilla, however, would open the door for the winner of the match between Espanyol or Real Sociedad, who meet in Barcelona, to overtake Athletic and claim the final Europa League spot for themselves.
Espanyol have four wins and three draws in their last seven games, while their rivals travel to Barcelona following three straight wins, including a 3-1 triumph at home to Real Madrid last weekend.
None of the weekend's other games have any bearing on the outcome of the season, as Atletico Madrid, who on Tuesday confirmed that Antoine Griezmann will leave the club this summer, visit Levante.
FC Barcelona visit Eibar and with Luis Suarez, Philippe Coutinho and Ousmane Dembele all injured, coach Ernesto Valverde is unlikely to risk Lionel Messi ahead of next weekend's Copa del Rey final, meaning youngster Abel Ruiz could get another chance after impressing against Getafe.
Finally, Real Madrid draw the curtain on what for them has been a disastrous season with a home game against Real Betis, which many believe will be Keylor Navas and Gareth Bale's last appearances for the club.
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