Serena Williams can pose as huge threat to Osaka in the quarterfinals, but the 23-time Grand Slam winner has just played one match on clay after last year's tournament.
The top half also featured the title holder Simona Halep, who might take on Petra Kvitova after making into the last eight.
Second-seeded Karolina Pliskova can expect No. 5 seed Angelique Kerber as a potential quarterfinal opponent.
American veteran Venus Williams and No. 9 seed Elina Svitolina will fight for a second round spot. Both were drawn in the same quarter with Sloane Stephens and Kiki Bertens.
The 16th-seeded Wang Qiang and Zheng Saisai set up an all-Chinese clash in the first round. The winner would see Halep across the net if making her way to the last 16.
Zhang Shuai kicks off her campaign against a qualifier, while Zhu Lin faces Romania's Irina-Camelia Begu.
Wang Yafan, the other Chinese player out of five, plays Marketa Vondrousova and would challenge Kerber if advanced.
The 2019 French Open will start on Sunday until June 9.
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