"I was just waiting for her to get a little bit tired. I think she did towards the end of the second set and the third set. That's when I just tried to really accelerate on how fast I was sort of winning the points," Osaka noted.
The 23-time Grand Slam winner Serena Williams outclassed Japan's Kurumi Nara 6-3, 6-2.
"She was playing really good tennis the whole time, and I just had to play a little bit better," Williams pointed out.
Defending champion Simona Halep was also made to sweat, as she squandered three match points before getting past Magda Linette 6-4, 5-7, 6-3.
Wang, the last Chinese player remaining in singles draw, fell 6-3, 6-0 to Polish youngster Iga Swiatek.
"She played really well and aggressive, and could attack my balls," admitted Wang, adding that her 17-year-old opponent has the prospect of reaching top 10 on ranking if she keeps playing like that.
Following their Australian Open success earlier this year, China's Zhang Shuai and partner Samantha Stosur of Australia eased past Veronika Kudermetova and Galina Voskoboeva 6-3, 6-0 into women's doubles second round.
Zhang's compatriot Xu Yifan, along with Canada's Gabriela Dabrowski, also marched on, but Chinese pairing of Jiang Xinyu and Wang Qiang slid away with a 6-2, 6-2 loss.
Yang Zhaoxuan triumphed in women's doubles first round with Polish partner Alicja Rosolska, but lost her mixed doubles opener with Maximo Gonzalez of Argentina.
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