Substitute goalkeeper Yohann Pele, in place of forward Mario Balotelli, had to get the ball from the net after falling in front of Di Maria's stunning free-kick won through Mandanda's foul.
Pele could feel somewhat a bit consolation after denying Mbappe's stoppage-time penalty.
PSG stay unbeaten in their last 19 meetings with Marseille in all competitions since their latest loss back in November 2011.
Lyon edged Montpellier 3-2 at home to close on the second place with a four-point deficit from Lille.
Despite seeing his initial attempt denied by goalkeeper Benjamin Lecomte, Martin Terrier managed to move the hosts ahead 12 minutes into the match. However, that was cancelled out by Florent Mollet's free-kick in the 36th minute.
Lyon striker Moussa Dembele continued his recent momentum as he latched onto Tanguy Ndombele's stitching pass to sweep his 12th league goal of the campaign in the 58th minute.
Mollet might have thought that his second goal of the match arrived in the 68th minute, only to see that ruled offside. Two minutes later, Lyon captain Nabil Fekir wasted a penalty by firing it quite wide.
But Lyon still bagged victory into their pocket with Hossem Aouar's header with four minutes remaining. Souleymane Camara reduced Montpellier's deficit two minutes into stoppage time.
With nine matches to go, Lyon put up their strong contention for second place and automatic qualification for next season's Champions League.
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