Tottenham coach Mauricio Pochettino will start a two-game ban for a post-game argument with referee Mike Dean, when Spurs visit his former club Southampton on Saturday.
Spurs reached the last eight of the Champions League in midweek, but need to pick up their domestic form after taking just one point from the last nine available, a run which coincides with Harry Kane's return to fitness.
Arguably the most interesting clash of the weekend sees fifth placed Arsenal entertain fourth placed Manchester United in 90 minutes which could be vital to see who eventually qualify for next season's Champions League.
United travel to London after their incredible Champions League win over Paris Saint Germain and unbeaten in the league since Ole Gunnar Solskjaer took over from Jose Mourinho.
Solskjaer told the press on Friday that Antony Martial will be back from injury, as will Nemanja Matic and possibly Ander Herrera, but he will also be aware that his side has a much tougher run into the end of the season than Sunday's rivals.
Things have picked up at Chelsea over the past two weeks as highlighted by Thursday's 3-0 Europa League win over Dynamo Kiev, and Maurizio Sarri will expect three points against Wolves, who beat Chelsea in their first meeting of the season.
Elsewhere Brendan Rodgers makes his home debut as Leicester City coach at home to Fulham, where Scott Parker is in charge for his second match. The game comes after Rodgers' home in Scotland was burgled with his wife and daughter still inside, something he described as "horrendous".
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