With the result, Leipzig cement their fourth place in the standings whereas Stuttgart remain on the 16th position, which is a relegation play-off spot.
Elsewhere, Mainz suffered their third straight loss as goals from Wolfsburg's Maximilian Arnold, Wout Weghorst and Robin Knoch were enough to secure all three points.
Hoffenheim showed no mercy to the bottom side Hannover as Joelinton, Ishak Belfodil and Kerem Demirbay handed the hosts their 14th loss of the season.
Schalke and Freiburg played out a goalless stalemate meanwhile Claudio Pizarro's late equalizer snatched Bremen a 1-1 draw at Berlin.
The following fixtures are set for Sunday: Eintracht Frankfurt host third placed Borussia Monchengladbach, and Bayer Leverkusen encounter Fortuna Dusseldorf.
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