With two matches in hand, PSG restore their 13-point advantage over second-placed Lille, who won at Caen 3-1 on Friday.
Guingamp failed to maintain their momentum in recent weeks against Saint-Etienne. Wahbi Khazri scored the only goal of the match with a superb free-kick in the seventh minute.
Guingamp almost leveled the score in the 62nd minute, but Ronny Rodelin's shot was denied by the post.
Saint-Etienne move within a touching distance from the top three, level on points with third-positioned Lyon.
Elsewhere, Nice edged Bordeaux 1-0 through Allan Saint-Maximin's spot kick in the 16th minute.
Spanish midfielder Cesc Fabregas is expected to make his Monaco debut on Sunday when the league strugglers visited Marseille.
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