Newcastle United's Miguel Almiron was deployed as a false nine with Oscar Cardozo relegated to the bench.
As expected, Paraguay were content to concede possession for long periods in an effort to hit Brazil on the counterattack.
The hosts had 67% of the ball in the first half but only three shots on target compared to Paraguay's one.
Firmino was presented with a chance to put the hosts ahead in the opening minutes but his tame 20-yard effort was comfortably saved by Fernandez.
Paraguay's best opportunity of the opening period came when Perez whipped a diagonal cross to Gonzalez at the far post before seeing his shot tipped behind by Alisson.
Brazil started the second half in a more lively mood, using quicker triangular passes in an effort to unlock Paraguay's defence.
Arthur sent a rasping 25-year effort over the bar and Dani Alves threaded a pass to Firmino, who was knocked down by Balbuena just outside the penalty box with only the goalkeeper ahead of him.
The game was delayed for more than five minutes as Chilean referee Roberto Tobar consulted the video assistant referee before showing the defender a straight red card.
Gremio forward Everton showed why he is reportedly attracting the interest of several European clubs by menacing the right side of Paraguay's defence. The 23-year-old brought the crowd to their feet in the 74th minute by beating his marker and firing a perfect cross to Gabriel Jesus, who nodded wide from the edge of the six-yard box.
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