Ben Youssef should have scored again two minutes later but sent a shot straight at Penedo when he had only the goalkeeper to beat.
Panama were under sustained attack and there was a sense of inevitability about the goal that put them behind in the 66th minute.
Oussama Haddadi began the move with a slide-rule pass from the left and Khazri was perfectly positioned at the far post to fire in his 14th international goal.
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