With the victory, Mainz climb off a relegation play-off spot and onto 14th position of the standings while Leipzig continue on the 6th place of the standings.
Elsewhere, Borussia Dortmund missed the chance to jump on the 2nd place, as Werder Bremen held the BVB to a 1-1 draw.
Marco Reus broke the deadlock before Thomas Delaney restored parity before the half time. Dortmund pressed for the victory but the woodwork and Bremen's in-form goalkeeper Jiri Pavlenka saved the hosts one point on home turf.
Dortmund remain on the 3rd place of the standings whereas Bremen continue on 12th position.
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