In sporting terms, Pique's injury, combined with that of Thomas Vermaelen could hand Yerry Mina his Barcelona debut alongside Samuel Umtiti in the Barca defense, while Jordi Alba and Sergi Roberto both return along with Ivan Rakitic and Leo Messi, all of whom were rested at the weekend.
Valencia's main issue is whether or not to risk Goncalo Guedes' fitness down the left wing or to play two full backs Tony Lato and Jose Gaya down the flank.
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