Bayern retracted with the two-goal lead and allowed the hosts to produce opportunities. However, Mainz were not able to pull one back as Robin Quaison, Yoshinori Muto and Abdou Diallo failed to overcome Bayern goalkeeper Sven Ulreich.
With the result, Bayern increase their advantage atop the table to 18 points while Mainz suffered their second loss in row to drop to the 16th place, which is a relegation play off spot.
Struggling Werder Bremen shocked top-four team Schalke with a late comeback win in the dying minutes of the game.
The "Royal Blues" controlled the proceedings on the pitch but lacked in penetration against Bremen's well-positioned bulwark.
Nevertheless, Schalke opened the scoring with 21 minutes into the game as Bremen goalkeeper Jiri Pavlenka fumbled Yevhen Konoplyanka's shot into the goal.
Schalke suffered a setback after the restart as Matija Nastasic booked his second yellow card to receive his marching orders in the 78th minute.
Things went from bad to worse as the "Green-Whites" got rewarded for their resilient performance in 79th minute when Max Kruse benefitted on a rebound following a free kick to level the scores.
Werder Bremen capitalized on their superior number and grabbed the 2-1 victory in the dying minutes of the game as Zlatko Junuzovic poked home the winner from very close range.
With the win, Bremen climbed out of the bottom three and jumped onto the 15th place meanwhile Schalke slipped from the 3rd to the 4th position.
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